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Jean Givens
Jean Givens
United States, Lexington
14 Nov 2018
I have used Revolution in the past and been happy with it. I decided to foster two cats for a few months, and switched to an inex ... more
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Flea & Tick Treatments Comparison Chart

Helping you decide which flea & tick treatment is best for your dogs and cats

Fleas and ticks are probably the most common parasites associated with dogs and cats, but the issues they cause should not be underestimated. Fleas can be particularly hard to eradicate due to their fast breeding cycle – an adult flea can lay up to 50 eggs a day. Fleas cause itching and irritation which can distress your pet, with some developing flea allergy dermatitis.

Ticks may not be as prevalent, but can carry dangerous and deadly diseases including Rocky Mountain Spotted Fever, St. Louis encephalitis, Lyme disease, tick paralysis and more.

There are plenty of flea and tick treatment options available, all with their pros and cons. It is important that you consider the needs of your pet and household before selecting the right treatment. For example: topical or spot on treatment could be good for a pet that will not take medication, but oral treatments might more suitable for a multi-pet household or where fast acting treatment is required. The stage of flea or tick infestation also determines whether you will need a knock down treatment or a preventative one.

We have compared some of the major brands of flea and tick treatments available to help you decide on the most effective solution for you and your pets.

Brand For Active Ingredient(s)/Application Kills Fleas Repels Fleas Kills Flea Eggs and Larvae Kills Ticks Repels Ticks Kills and/or Repels Mosquitoes Safe for Pregnant or Nursing Pets
Activyl Dogs & Cats Indoxacarb
Monthly; Topical
yes tick - yes tick - - - -
Advantage II Dogs & Cats Imidacloprid, Pyriproxyfen
Monthly; Topical
yes tick - yes tick - - - yes tick
Advantage Multi Dogs & Cats Imidacloprid, Moxidectin
Monthly; Topical
yes tick - - - - - -
K9 Advantix II Dogs Imidacloprid, Permethrin, Pyriproxyfen
Monthly; Topical
yes tick yes tick yes tick yes tick yes tick yes tick yes tick
Bravecto Dogs Fluralaner
Every 12 weeks; Pork-flavored chewable
yes tick - Kills newly emerged fleas before they can lay eggs yes tick - - yes tick
Capstar Dogs & Cats Nitenpyram
Can be given daily; Unflavored tablet
yes tick - - - - - yes tick
Comfortis Dogs Spinosad
Monthly; Beef-flavored tablet
yes tick - - - - - Consult your veterinarian first
Credelio Dogs Spinosad
Monthly; Beef-flavored tablet
yes tick - - yes tick - - -
Frontline Gold Dogs & Cats Fipronil, S-methoprene, Pyriproxyfen
Monthly; Topical
yes tick - yes tick yes tick - yes tick yes tick
Frontline Plus Dogs & Cats Fipronil, (S)-Methoprene
Monthly; Topical
yes tick - yes tick yes tick - yes tick yes tick
NexGard Dogs Afoxolaner
Monthly; Beef-flavored chewable
yes tick - Kills newly emerged fleas before they can lay eggs yes tick - - -
Revolution Dogs & Cats Selamectin
Monthly; Topical
yes tick - Prevents flea eggs from developing yes tick - - yes tick
Seresto Dogs & Cats Flumethrin, Imidacloprid
Every 8 months; Collar
yes tick yes tick yes tick yes tick yes tick - Consult your veterinarian first
Simparica Dogs Sarolaner
Monthly; Liver-flavored chewable
yes tick - - yes tick - - -
Trifexis Dogs Spinosad, Milbemycin Oxime
Monthly; Beef-flavored tablet
yes tick - yes tick - - - -
Vectra 3D Dogs & Cats Dinotefuran, Pyriproxyfen, Permethrin
Monthly; Topical
yes tick yes tick Prevents all flea stages (eggs, pupae, larvae, and adult fleas) from developing yes tick yes tick yes tick Consult your veterinarian first

Comparing Flea & Tick Treatments for Dogs and Cats

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