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Common brand names

Single ingredient

No generic products are available.

Uses of Nitenpyram

Nitenpyram is an antiparasitic (neonicotinoid) used to kill fleas on dogs and cats. It has no effect on other external parasites including ticks, mites and lice.

Method of application

Oral application supplied as tablets.

Dosage and administration

Nitenpyram oral tablets are for use on both dogs and cats. Correct dosing is vital to avoid toxicity, so please weigh your pet before administering and use only as directed.

Tablets should be hidden in food or placed directly into the animal’s mouth. Monitor your pet to ensure the entire dose has been swallowed. If you suspect the tablet has not been swallowed, it is safe to administer a second dose.

Nitenpyram kills existing adult fleas on dogs and cats, but provides no protection against reinfestation. If you pet becomes reinfested with fleas, Nitenpyram may be administered again, up to once per day.

For maximum effectiveness, treat all pets in the household at the same time.

Nitenpyram has no effect on fleas in the home or in the pet’s environment. As eggs and immature fleas develop and attach to your pet, it may be necessary to readminister Nitenpyram.

Possible side effects

There may be a brief period of intense scratching after treatment with Nitenpyram. This is due to fleas biting as they are killed, and is not an adverse reaction to the medication.

Reported side effects in dogs treated with Nitenpyram include lethargy, vomiting, itching, decreased appetite, diarrhea and hyperactivity.

Reported side effects in cats treated with Nitenpyram include hyperactivity, panting, lethargy, itching, vocalization, vomiting, fever and decreased appetite.


Toxicity occurs most frequently due to dosing errors. Please ensure you use only as directed.

Safe for use with pregnant or lactating dogs or cats.

Not for use on dogs or cats under 4 weeks of age.

Not for use on dogs or cats weighing less than 2 pounds (0.9 kg).

Signs of toxicity

Indications of Nitenpyram overdose in dogs and cats include fatigue, convulsions, difficulty breathing, tremors, cramps and unstable gait.

In addition, cats may experience drooling, vomiting and rapid breathing.

If you suspect your pet has had an overdose, please contact your veterinarian immediately.


Store at controlled room temperature, between 59° and 77°F (15°-25°C).


This information is provided for general reference only and is not intended to replace the packaging label or veterinary advice. This page may not include all side effects, uses, brand names or applications.


Nitenpyram drug information sheet
Nitenpyram Information Sheet

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