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What is Advantage Multi?

Advantage Multi is a broad-spectrum parasite treatment available in products for both dogs and cats. It works at various parasite life stages and can be used as an alternative to Revolution.

Advantage Multi for Dogs prevents heartworm disease, kills fleas (Ctenocephalides felis), and treats common intestinal parasites including roundworm, hookworm, and whipworm. It can also be used in the treatment and control of sarcoptic mange.

Advantage Multi for Cats kills adult and egg fleas and treats and controls ear mites, heartworms, hookworms, and roundworms. Advantage Multi for Cats has also been FDA approved for the treatment fleas and heartworm disease in ferrets over 2 pounds (0.9 kg).


  • Topical treatment ensures the product is not refused
  • Dogs are protected from heartworm disease even after bathing (from 90 minutes after treatment)
  • Broad spectrum treatment controls multiple parasites
  • Month-long coverage

Is Advantage Multi suitable for my dog or cat?

Advantage Multi for Dogs is for use on dogs and puppies over 7 weeks of age and with a body weight of at least 3lbs (1.4kg) minimum.

Advantage Multi for Cats is for use on cats and kittens over 9 weeks of age and with a body weight of 2lbs (0.9kg) minimum.

Dosage Schedule

Advantage Multi is a topical treatment designed to be used once a month.

The dosage for both dogs and cats is based on the animal’s body weight - please ensure you have the correct product for your pet’s size.

Advantage Multi for Dogs

Body weight Volume (ml) Imidacloprid (mg) Moxidectin (mg)
3-8.8 lbs (1.4-4 kg) 0.4 40 10
8.8-22 lbs (4-10 kg) 1 100 25
22-55 lbs (10-25 kg) 2.5 250 62.5
Over 55lbs (25 kg) 4 400 100

Advantage Multi for Cats

Body weight Volume (ml) Imidacloprid (mg) Moxidectin (mg)
2-8.8 lbs (0.9-4 kg) 0.4 40 4
8.8-17.6 lbs (4-8 kg) 0.8 80 8


What are the side effects of Advantage Multi?

The most common reported side effects in dogs is pruritis. Residue and medicinal odor have also been reported.

Adverse reactions reported in cats include behavioral changes, discomfort, and lethargy. Excessive salivation and polydipsia have also been reported.

What precautions must be taken?

  • Do not administer orally – topical application only.
  • Wash hands thoroughly with soap and warm water after application.
  • Keep out of reach children and animals.
  • Not for human use.
  • Ensure the pet or other animals can not lick the area of application for 30 minutes after administration.

Advantage Multi for Dogs

  • Advantage Multi for Dogs should not be used on cats.
  • Not for use on dogs and puppies under 7 weeks of age or under 3lbs in weight.
  • Advantage Multi for Dogs has not been evaluated in heartworm-positive dogs with class 4 heartworm disease.
  • The safe use of Advantage Multi in breeding, pregnant or lactating dogs has not been evaluated.
  • Children should not come into contact with application sites for 2 hours after administration.

Advantage Multi for Cats

  • Advantage Multi for Cats should not be used on dogs.
  • Not for use on cats and kittens under 6 weeks of age or under 2lbs in weight.
  • The safe use of Advantage Multi in breeding, pregnant or lactating cats has not been evaluated.
  • The effective use of Advantage Multi for Cats against heartworm infections after bathing has not been evaluated in cats.
  • Children should not come into contact with application sites for 30 minutes after administration.

How effective is Advantage Multi (imidacloprid + moxidectin)?

Advantage Multi for Dogs: A 56-day field safety study was conducted in 214 D.immitis heartworm and microfilariae positive dogs with Class 1, 2 or 3 heartworm disease. All dogs received Advantage Multi for Dogs on Study Days 0 and 28; 108 dogs also received melarsomine dihydrochloride on Study Days – 14, 14, and 15. All dogs were hospitalized for a minimum of 12 hours following each treatment. Effectiveness against circulating D. immitis microfilariae was > 90 % at five of six sites; however, one site had an effectiveness of 73.3%. The microfilariae count in some heartworm-positive dogs increased or remained unchanged following treatment with Advantage Multi for Dogs alone or in a dosing regimen with melarsomine dihydrochloride.

Brand Comparison

Advantage Multi for Dogs & Cats

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    Clayton Cole
    Happy Cats
    We have a total of 21 cats and a dog that are indoor pets that we let out an hr/day in the backyard. Of that, 5 are stray/feral, so it's important we give them flea/worm medicine -couldn't catch but 3 strays. It gets very expensive that's why I shop on here since 2017. I have tried Revolution, Stronghold, and recently, Advocate, I got a few Milbemax tabs mainly for the 3strays. All of them works. But there was one order that I had that Stronghold did not kill fleas -had to quickly buy at a local store. I don't know why, so I switched to Advocate. Shipping takes about 3wks though, but for the price and convenience, I'm okay w/it. Thank you Petbucket!
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