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Heartworm Treatments Comparison Chart

A guide to help you decide which heartworm treatment is right for your dogs and cats

Heartworm is a particularly dangerous parasite that can prove fatal in both dogs and cats. It can be very difficult to treat once established, so it is particularly important to include a heartworm preventative as part of your pet’s treatment routine.

As heartworm is transmitted by biting insects such as mosquitoes, dogs and cats can become infected without coming into contact with other animals, even if they are indoor-only pets.

With the number of heartworm preventatives available, choosing the right treatment for your pet can be overwhelming. Some things you might want to consider is whether you are treating a dog or cat, whether you want a topical or oral treatment, and the active ingredients. Some heartworm medications also provide broad-spectrum treatment against other intestinal parasites such as roundworms, hookworms, whipworms and tapeworms.

We’ve compared some of the major heartworm preventative treatments below to help make your options easier to understand.

Brand For Active Ingredient(s)/Application Prevents Heartworm Prevents Roundworms Prevents Hookworms Prevents Whipworms Prevents Tapeworms Safe for Pregnant or Nursing Pets
Advantage Multi Dogs & Cats Imidacloprid, Moxidectin
Monthly; Topical
yes tick yes tick yes tick yes tick - -
Heartgard Plus Dogs Ivermectin, Pyrantel Pamoate
Monthly; Beef-flavored chewable
yes tick yes tick yes tick - - yes tick
Interceptor Dogs & Cats Milbemycin Oxime
Monthly; Beef-flavored tablet
yes tick yes tick yes tick yes tick - yes tick
Interceptor Plus Dogs Imidacloprid, Praziquantel
Monthly; Topical
yes tick yes tick yes tick yes tick - -
Revolution Dogs & Cats Selamectin
Monthly; Topical
yes tick yes tick
Cats only
yes tick
Cats only
- - yes tick
Sentinel Dogs Milbemycin Oxime, Lufenuron
Monthly; Beef-flavored tablet
yes tick yes tick yes tick yes tick - yes tick
Sentinel Spectrum Dogs Milbemycin Oxime, lufenuron, and praziquantel
Monthly; Beef-flavored chewable
yes tick yes tick yes tick yes tick yes tick yes tick
Tri-Heart Plus Dogs Ivermectin, Pyrantel
Monthly; Beef-flavored chewable tablets
yes tick yes tick yes tick - - -
Trifexis Dogs Spinosad, Milbemycin Oxime
Monthly; Beef-flavored tablet
yes tick yes tick yes tick yes tick - -

Comparing Heartworm Treatments for Dogs and Cats

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