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Trifexis vs Comfortis

Compare Trifexis Tablets to Comfortis Tablets

Comfortis is a straight flea treatment, administered as a monthly tablet. It kills existing and emerging adult fleas for a month, preventing them from laying eggs.

Trifexis, also a monthly tablet, is a broad-spectrum parasite treatment. By the addition of an extra active ingredient (Milbemycin Oxime), it kills fleas at all life stage and also prevents heartworm, roundworms, hookworms, and whipworms.

Trifexis is safe for use in dogs and puppies at least 8 weeks of age, weighing 5 lbs (2.3kg) minimum. Trifexis tablets should not be administered to cats.

Comfortis is available for both dogs and cats. Comfortis may only be administered to dogs over 14 weeks, weighing 5 lbs (2.3kg) minimum, and cats over 14 weeks, weighing 4.1 lbs (1.9kg) minimum.

Top tip: Fleas and ticks can carry nasty diseases, but protecting your pet doesn’t need to be difficult. Use our comparison chart to weigh up the pros and cons of the most popular products.

  Trifexis Comfortis
Kills Fleas yes tick yes tick
Repels Fleas - -
Kills Flea Eggs and Larvae yes tick -
Prevents Heartworm yes tick -
Prevents Roundworms yes tick -
Prevents Hookworms yes tick -
Prevents Whipworms yes tick -
Other Parasites    
Safe for Pregnant or Nursing Pets - Consult your veterinarian first
When does it starts working Kills fleas within 30 minutes; kills 100% of fleas within 4 hours Kills fleas in 30 minutes
Application Beef-flavored tablet Beef-flavored tablet
Active Ingredient(s) Spinosad, Milbemycin Oxime Spinosad
Dosage Monthly Monthly

Trifexis vs Comfortis

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