Heartgard Plusの駆虫治療による副作用

May 13, 2014 • simone

Heartgard Plusの駆虫治療による副作用

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「予防は治療に勝る」ということわざは、ペットの寄生虫対策においてほど真実で重要なものはありません。回虫、鉤虫、フィラリアは蚊や糞便を介して容易に感染するため、ペットによく見られます。治療せずに放置すると、寄生虫は広がり増殖し、ペットの腸や呼吸器系に深刻な合併症を引き起こすおそれがあります。寄生虫感染は、重い消化器トラブルや心不全、さらにはペットの死につながることもあります。 

寄生虫は人にも感染する可能性があるため、効果的な駆虫ケアプランが不可欠です。 感染予防は定期的に行う必要があります。幸い、Heartgard Plusは毎月投与でき、与えやすく、安全性と効果が実証された駆虫薬です。寄生虫が危険な成虫段階まで成長するのを防ぎ、 犬と猫の両方にご利用いただけます。 

すべての子犬や犬は、寄生虫にさらされた経験がある可能性が非常に高いといえます。子犬は生後12週齢まで2週間ごとに駆虫を行う必要があり、授乳中のメスにも処置が必要です。12週齢を超えた犬には、生涯を通じて頻繁な投与が必要です。 

Heartgard Plusは、体重の異なる動物に合わせた各種用量をご用意しています。チュアブルタイプのおいしい錠剤です(私の観察によると)。丸飲みではなく噛んで食べるように設計されているため、必要に応じて砕いてペットのフードに混ぜることもできます。ペットが全量を摂取したことを確認する必要があるため、投与中と投与後しばらくは様子を観察してください。

フィラリアの治療を始める前には、必ず獣医師に相談することが非常に重要です。適切な用量を確認するためだけでなく、すでにフィラリアに感染している動物にフィラリア薬を投与すると、中毒性ショックに似た重い反応が起きる場合があるためです。犬は検査を受け、感染している場合は、駆虫プログラムを始める前に成虫のフィラリアと幼虫(ミクロフィラリア)の治療を行う必要があります。

今ちょうどおいしい食事を楽しんでいるなら、これからおぞましく悪役のような小さな寄生虫たちを詳しく見ていくので、ひとまず食事は脇に置いておくのがおすすめです。

回虫
回虫(アスカリッド)は、犬と猫に最もよく見られる寄生虫です。 
ほぼすべての子犬は、生まれた時点で回虫に感染しているか、母乳を通じて感染します。 

成虫は腸内に生息し、幅2~3mm、長さは最大20cmまで成長します。回虫は下痢や嘔吐、体重減少、発育不良、お腹の膨らみ、元気消失を引き起こします。治療せずに放置した場合や重症例では、肺炎や腸・消化管の閉塞が起こることがあります。

感染した動物では、成虫が卵を産み、それが糞便とともに排出されます。ほかの動物は、汚染された土を口にしたり、マウス、げっ歯類、鳥など感染した動物を食べたりすることで感染します。卵は動物の胃の中で孵化し、そこで見つかる内容物を栄養にして、産卵する成虫へと成長します。回虫の幼虫と成虫は肝臓や肺などほかの臓器にも見られることがありますが、一般的には消化器系にとどまります。 

鉤虫
鉤虫も腸内寄生虫の一種で、主に若い犬や猫に感染します。虫は宿主動物の腸壁に付着し、血液、組織、体液を栄養にします。回虫と同様に、幼虫と産卵する成虫は腸内に生息します。一部の幼虫はほかの臓器に付着し、呼吸器系を移行する場合は、ペットにとって特に問題となることがあります。 

鉤虫の卵は動物の糞便中に排出されます。犬や猫は、汚染された土を口にしたり、幼虫が皮膚から侵入したりすることで感染します。子犬は母乳を通じて感染することもあります。

 

血便を伴う下痢は、鉤虫の一般的な症状です。ほかにも、腸の不調、歯ぐきが白っぽくなる、体重減少、発育不良、被毛の状態悪化などの感染兆候があります。虫が多数寄生している場合や子犬では、深刻な失血や貧血が起こることがあります。極端な場合には死に至ることもあります。

フィラリア
フィラリアはすべての寄生虫の中で最も致死的で、犬での感染がより一般的ですが、猫も感染する可能性があります。虫は動物の肺、心臓、肺動脈に寄生し、心不全や死を引き起こすことがあります。 
子犬は遅くとも生後12週齢までにフィラリア予防を開始する必要があります。 

フィラリアで主に影響を受けるのは肺ですが、心臓、循環器系、さらには肝臓や腎臓にも損傷が及ぶことがあります。フィラリア感染を示す症状には、咳、息切れ、呼吸音、失神、元気消失、体重減少、唾液や粘液への血液の混入、腹部膨満、嘔吐、食欲不振があります。

フィラリアは蚊によって媒介され、感染した蚊が別の動物を刺すと、フィラリアの幼虫(ミクロフィラリア)が移されます。これらの幼虫は組織や宿主動物の循環器系を通って肺、心臓、肺動脈へ移動し、血液を栄養に成長します。成虫の中には長さ30cm、幅2cmに達するものもいます。フィラリアの幼虫は、宿主動物の血流中で2年間生存できます。 

フィラリアは組織の炎症、血液凝固、血管壁の肥厚を引き起こします。動物の血圧は上昇し、心臓への負担が増大します。 

すでにフィラリアに感染している犬に予防薬を投与した場合、非常に重い副作用が起こることがあります。

副作用
どの薬にも、不快な副作用や一部のペットにおける個体差による過敏反応の可能性があります。しかし試験では、 Heartgard Plusは正しく使用した場合に安全で忍容性が高く、消化器系および神経系の副作用の発生率は非常に低いことが示されています。 

Heartgard Plusには、寄生虫を麻痺させ死滅させるイベルメクチンが使用されています。Heartgardに含まれるイベルメクチンの用量は比較的少なく、副作用のリスクはほとんどありません。前述のとおり、ペットにフィラリア感染がないことを確認する前に駆虫プログラムを始めないことが極めて重要です。 

推奨量を超える投与は重い副作用につながることが多いため、ペットに必要な用量を確認してください。正しい用量を投与しても、以下に挙げる副作用が見られた場合は、直ちにペットを獣医師のもとへ連れて行ってください。

  • 消化器トラブル。Heartgard Plusに関連する最も一般的な副作用は、吐き気、嘔吐、下痢などの消化器トラブルです。臨床現場での試験では、投与後24時間以内に嘔吐または下痢が確認されたのはわずか1.1%でした。
  • よだれの増加
  • 抑うつと元気消失。 一部のペットでは、抑うつ、元気消失、食欲不振、活動への興味の喪失が見られています。
  • 協調運動障害(運動失調)、見当識障害、後肢麻痺
  • よろめく、壁や家具にぶつかる、麻痺が起こることがあります。
  • 散瞳(瞳孔拡張)または失明
  • 鳴き声、興奮
  • 低体温・体温低下
  • 発作と筋肉の震え。発作、震え、けいれんは非常にまれですが、ペットに特有の過敏性がある、用量が多すぎる、またはすでにフィラリアに感染していたことを示す場合があります。 

感受性の高い犬種
一部の犬種には多剤耐性遺伝子(MDR1)の変異があり、非常に高い用量(推奨量の16倍)ではイベルメクチンへの感受性が高くなります。試験では、Heartgardの推奨用量の10倍を投与した犬に有害反応は確認されませんでした。

この遺伝子変異は、コリー、オーストラリアン・シェパード、シェルティ、ロングヘアード・ウィペットなどの犬種で特に多く見られることが知られています。 フィラリア予防に使用されるイベルメクチンの量は一般に安全で、これらの犬にも適した低用量です。愛犬の遺伝子変異検査については、獣医師に 相談できます。

用量と治療の指示に従って使用すれば、 Heartgard Plusは安全で効果的な駆虫ケアプランです。生後6週齢の動物、妊娠中または授乳中の猫と犬にも承認されています。毎月ペットにチュアブルおやつを与えるだけで、簡単に投与できます。パッケージにはカレンダーも付いているので、投与時期を見失う心配もありません。安心はこれまでになく簡単です。 

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コメント(29)

  1. Melody

    Our dog was positive on his heartworm test but they gave him prednisone an muscle relaxers plus heartguard....we thought he was dying lastnight because all he did was lay there eyes were dialated and he would cough and had this mucous and foam type drooling....we thought he would die during night for sure but today he is getting up some an nodrool.....happening.....he reallying scared us???????????????

  2. Sheree' Welch

    My dog Molly was treated for heartworms in July last year & was heartworm free at her 6 month check up. As suggested, I've continued to give her heartguard monthly. However, for the past 2 minths, I've noticed her coughing the day after it's given & the cough lasts a day or two. Suggestions?

  3. Shirley

    Might gave my 8 year old dog heartguard plus this morning. Tonight her back legs are not working. Is there anything I can do for her right now and will this pass

  4. Marcy

    Did your dog get better? I gave two of my dogs ther Heartguard Plus last night. One is perfectly fine the other is having trouble with her back legs. She doesn’t seem to be in any pain and she will get up to go to go outside however she struggles with getting her back legs to walk.

  5. Natalie Wood

    My dogs hind legs are having problems too. How are yalls dogs now?

  6. Jody Creighton

    I gave my Lab/Basset her Heartguard dose Sunday and since the following Tuesday her back left leg has hurt her. I’ve been researching hip dysphasia symptoms and joint pain in senior dogs but thought I’d check to see if MAYBE any other dogs had leg pain after their heart worm meds and found this thread. Did your dogs leg issues clear up?

  7. Jody

    Did your dogs leg issues get better? I gave all 4 of mine Heartguard Sunday and Tuesday one of my dogs started having back leg pain. She still seems like it’s bothering her.

  8. Troy

    I have a 2 year old shepherd we adopted. They agency said she was Heartworm free. We did a Heartworm test after we had her and we had been giving heart heart guard( I have a lab too which has been on Heartgard no issue) she was diagnosed last year with micro flare and we started the slow kill treatment with heart guard plus. Last year she had a spell we’re she just payed down and like she passed out. We rushed her to dr and they gave her a Benadryl and she was fine in about and hour. This was during the slow kill treatment. We had her tested last year after the slow kill and test showed Heartworm free. She had another spell 3 weeks ago and it was worse. I picked her up and carried her to Dr and she just payed there with trashy clinches. He ran blood work ( liver enzymes a little escalated) and exrays and everything was normal. He felt she had a seizure. He told us to bring her back (today) and he tested her again and liver was fine. He did test for Heartworm again and now she is back micro flare positive, not sure how we should proceed?
    HELP!!!!!

  9. Katy

    Hi,
    I am not an expert but I am a breeder. I have lost a breeding dog with HeartGard before, and my other dogs have had serious side effects, vomiting every day, and constantly being tired and depressed. It took about a week for them to heal. I did some research and it is because they're pesticides that some dogs can't handle. Most dogs can handle it with only minor side effects, but others have very serious side effects, and, in some cases, death. I have even had some clients who told me they lost their dog to this medecine. (HeartGard) The best solution is to avoid HeartGard and other pesticide medicines. Always go for the organic and natural ones!
    Hope your dog(s) feels better soon!

  10. Sharon

    My mixed breed adopted pup, 16 months old, had an issue back in the early winter with her hind legs to the point she ended up on steroids. During the rest of the winter I was a slacker when it came to giving the Heartgard Plus and her leg pain had resolved. I restarted the med on Saturday and Saturday evening she was limping so badly I had to help her into the bed. (She acted like her knee was painful). By Sunday morning she was barely limping, but even today the limp is still noticeable. I'm starting to wonder if there is a correlation.

  11. Sharon

    I gave My mixed breed adopted pup, 16 months old, had an issue back in the early winter with her hind legs to the point she ended up on steroids. During the rest of the winter I was a slacker when it came to giving the Heartgard Plus and her leg pain had resolved. I restarted the med on Saturday and Saturday evening she was limping so badly I had to help her into the bed. (She acted like her knee was painful). By Sunday morning she was barely limping, but even today the limp is still noticeable. I'm starting to wonder if there is a correlation.

  12. Steve

    My dog has the same issues. Everytime we give him heartgard plus he coughs for the next several days.

  13. Carla

    My German Shepherd has the Heartgard injection on Thursday, by Saturday night he could use his back legs. Still unable to stand this morning (Sun). Will it get better? How long dies it take?

  14. Nicole

    I gave my dog heart guard..I thought it was something else then again and same thing shaking leg pain ..I think it's the heart guard cause see the comments..how long does it last

  15. Arlene

    I gave my 8 week old puppy 1st dose of heartguard and had seizures the same day. I saw that convulsions can be a side effect. Brought her to the vet and liver enzymes were ok but still having seizure 1-2 x a day. Gave the medicine Dec 15. Vet said it’s just a coincidence because the med is safe for puppies. I’m worried. Help!

  16. Angela Cote

    I’ve given my dog Heartgard for over 4 years without issue but this month she has an episode where she lost control over her limbs and she was scared! She couldn’t walk and was trembling! A couple hours later she was totally fine. I can’t help but wonder if it was the Heartgard?

  17. Pat Wester

    My miniature schnauzer started having trembling in his back legs about a year ago. In June, 2020 he had an episode of stumbling and loosing control of his hind legs. I've had him to the vet and we've gone through a ton of tests including a consult with a neurologist and nothing. His last episode was in Nov. I have always taken him off Heartgard and Frontline during the cold months. It's been 14 weeks since he had an episode of problems in his back legs. I started researching the effects of Heartgard and Frontline and have become concerned that these drugs are the cause of his problems. He's 12 1/2 yrs. old. I'm not going to put him back on either of those drugs.

  18. Richard Coughlin

    Gave my lab heart guard plus ever since it’s had digest promblems

  19. Terry

    Did your dog get better with appetite and how long did it take?

  20. Kristi Burton

    3 outta my 4 dogs that have been giving heartgard had episodes of vomiting and diarrhea 2 to 3 days after each dosage. Living in Louisiana it is hard not to give preventative even though my dogs are inside dogs. But it has been 5 days since I gave another dose and now my french bulldog is having leg tremors and is very lethargic. I usually have healthy, happy dogs unless it is the mosquito time of the year. Everyone might as well spray the yard with pesticides instead of giving it as a treat, What is the difference? Heart worms will kill a dog but we need a better preventative solution. I DONT WANT MY DOG TO SUFFER from a medication or a parasite. I know this is why my dogs are acting this way because there is no other explanation. I gave my 2 boys imodium for 2 days and the diarrhea finally stopped, but had to use the adult pill the children's imodium did nothing. As for my girl, she is resting because I gave her a pain pill. Only thing I can do is wait for this stuff get out of their system and don't give it again. Off to the vet in the morning. Good luck everyone.

  21. Mon

    Our coonhound is allergic to one of the ingredients in heartguard and had terrible diarrhea after each dose. We've switched to interceptor and no more issues. Doesn't taste as good, but a little peanut butter does the trick.

  22. Kristi Burton

    thank you, we will try that.

  23. Lyss

    Do 8 week old puppies need heartgard? I thought they get dewormed at a very early age.

  24. Al Bendorf

    Gave my chiweenie Heartgard, had bruising, platelet count went down to 8K. After discontinuing, platelets back up to 200K. Dangerous medication!!

  25. Barb

    My lab is on heart guard plus year round. Does she need to be dewormed also

  26. sinan

    Yes, you need a dewormer like Drontal for intestinal worms.

  27. Robin

    My golden retriever is so tried after taking heartgard plus. How long will this last?
    He is 8

  28. Anonymous

    Same exact thing is happening with my pomeranian. Such a happy dog until I gave him heartgard. I'm suing. Contact me. (Email removed. We can not publish email addresses.)

  29. Amanda Dalton

    Thank you, I'm currently in the vet with a very sick baby 2 days after heartgaurd they keep telling me it couldn't be the heartgaurd. But she is having bloody stool so bad she needs IV and throwing up

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